Abstract: Objective: To develop sensitive indicators of nursing outcome for permanent colostomy patients with Omaha system and nursing outcomes classification system. Methods: Totally 27 experts were investigated using three rounds of Delphi consultation methods to get the common opinion of experts and develop sensitive indicators of nursing outcome for patient with permanent colostomy. Results: After three rounds expert consultation, the effective response rates were 96.6%, 100.0%, 96.4%, respectively, and the authorities coefficient were 0.895, 0.899, 0.909, respectively. The coordination coefficient of primary, secondary, and third indicators were 0.340, 0.379, 0.402, respectively, with P values all less than 0.01. The sensitive indicators of nursing outcome for permanent colostomy patients consisted of 4 domains, 10 first-1evel indicators, 21 second-level indicators, and 69 third-1evel indicators. Conclusion: The development of nursing outcome-based sensitive indicators could provide basis for targeted transitional nursing mode for permanent colostomy patients.