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中国科技核心期刊（中国科技论文统计源期刊）
中国科学引文数据库（CSCD）核心库期刊
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中国护理管理 ›› 2025, Vol. 25 ›› Issue (2): 185-190.doi: 10.3969/j.issn.1672-1756.2025.02.006

• 论著 • 上一篇    下一篇

造血干细胞移植术后患者及配偶亲密关系在二元应对与癌症复发恐惧间的中介效应

张秋会 徐丽 张玲 张会娟 刘贵英 刘玉秋 管伟 解文君 姜尔烈 张清   

  1. 中国医学科学院血液病医院（中国医学科学院血液学研究所）移植中心，300020 天津市（张秋会，张玲，张会娟，刘贵英，刘玉秋，管伟，姜尔烈）；护理部（徐丽，解文君）；天津医科大学护理学院（张清）
  • 出版日期:2025-02-15 发布日期:2025-02-15
  • 通讯作者: 张清，硕士，教授，E-mail:snzhangqing@126.com
  • 作者简介:张秋会，硕士，主管护师，护士长
  • 基金资助:
    北京协和医学院“中央高校基本科研业务费”（3332022061）

Mediating effect of intimate relationship on dyadic coping and Fear of Cancer Recurrence in patients after Hematopoietic Stem Cell Transplantation and their spouses

ZHANG Qiuhui, XU Li, ZHANG Ling, ZHANG Huijuan, LIU Guiying, LIU Yuqiu, GUAN Wei, XIE Wenjun, JIANG Erlie, ZHANG Qing   

  1. Department of Transplantation Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China
  • Online:2025-02-15 Published:2025-02-15
  • Contact: E-mail:snzhangqing@126.com

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摘要： 目的：调查恶性血液病行造血干细胞移植术后患者及配偶癌症复发恐惧的现状，构建亲密关系在夫妻双方二元应对与癌症复发恐惧的主客体互倚中介模型，为临床工作人员制定科学有效的二元干预措施提供理论指导。方法：采用便利抽样法，选取天津市某三级甲等专科医院2021年5月—12月住院及复查的恶性血液病行造血干细胞移植术后的249对已婚患者及配偶，采用一般资料调查问卷、恐惧疾病进展简化量表、配偶恐惧疾病进展量表、二元应对量表、Locke-Wallace婚姻调适量表进行调查，采用Amos?24.0软件进行主客体互倚中介模型的构建。结果：在主体中介方面，患者的积极二元应对、消极二元应对均可以通过自身的亲密关系作用于自身的癌症复发恐惧（β=-0.156、0.124），也可以通过配偶的亲密关系作用于患者的癌症复发恐惧（β=-0.085、0.025），配偶的消极二元应对只能通过自身的亲密关系作用于自身的癌症复发恐惧（β=0.213）；在客体中介方面，患者的积极二元应对、消极二元应对均可通过配偶的亲密关系作用于配偶的癌症复发恐惧（β=-0.274、0.096），配偶的消极二元应对可以通过自身及患者的亲密关系作用于患者的癌症复发恐惧（β=0.055、0.060）。结论：恶性血液病行造血干细胞移植患者及配偶二元应对可通过夫妻双方的亲密关系作用于自身或配偶的癌症复发恐惧，提示医护人员应将患者及配偶作为一个整体进行二元干预，增进双方的亲密关系，降低夫妻癌症复发恐惧水平。

关键词: 造血干细胞移植；二元应对；亲密关系；癌症复发恐惧；主客体互倚中介模型

Abstract: Objective: To investigate the Fear of Cancer Recurrence (FCR) in patients with hematological malignancy after Hematopoietic Stem Cell Transplantation (HSCT) and their spouses, and construct the Actor-Partner Interdependence Mode extended to Mediation of intimate relationship on dyadic coping and FCR, providing theoretical guidance for clinical staff to develop scientifically effective dyadic intervention measures. Methods: By using convenient sampling method, from May to December 2021, a total of 249 hospitalized and reexamined patients after HSCT and their spouses were investigated with general information questionnaire, Fear of Progression Questionnaire-Short Form, Fear of Progression Questionnaire-Short Form/Partner, Dyadic Coping Inventory, the Lock-Wallace Marriage Relationship Adjustment Scale. Results: In terms of actor mediating effect, patients' positive dyadic coping and negative dyadic coping could affect their FCR through the intimate relationship on themselves' and their spouses', the spouse's negative dyadic coping could only affect their FCR through their own intimate relationship; in terms of partner mediating effect, patients' positive dyadic coping and negative dyadic coping could affect their spouse's FCR through their spouse's intimate relationship, spouse's negative dyadic coping could affect the patient's FCR through the intimate relationship on themselves' and their spouses'. Conclusion: The dyadic coping of patients after HSCT and their spouse can affect their own or their spouse's FCR through the intimate relationship between the husband and wife, which suggest that medical staff should carry out dyadic intervention on the patient and spouse as a whole, improving the intimate relationship and reducing the FCR.

Key words: Hematopoietic Stem Cell Transplantation; dyadic coping; intimate relationship; Fear of Cancer Recurrence; Actor-Partner Interdependence Mode extended to Mediation

中图分类号:  R47；R197
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