Abstract: Objective: To investigate the knowledge and ability of medication safety management in the discharged patients who were taking warfarin, and analyze the influencing factors. Methods: A total of 112 discharged patients taking warfarin were investigated using the knowledge and ability of medication safety questionnaire by telephone or face-toface interview. Results: Among all the items, most of the patients knew the correct time to take the medication, reported that they wouldn't stop the medication by themselves, and knew what to do if they forgot to take the mediation. But only few patients understood the influence on diets and living habits, and the need to see a doctor. Multiple stepwise regression analysis indicated that age, medication education and instruction reading entered the equation. The older patients had lower level knowledge and ability of warfarin taking safety. Patients who got medical health guidance and read the instruction had higher level knowledge and ability of medication safety. Conclusion: The knowledge and ability of warfarin taking safety management in the discharged patients were not adequate. Medical staff should educated the patients' in detail about the medication taking safety knowledge, encouraged them to read instruction, and implemented personalized medicine safety direction effectively.