Abstract: Objective: To analyze the effect of multidisciplinary cooperation on the optimization of process management in the inter-hospital transfer of critically ill patients with brain diseases. Methods: A process management team was set up to select the core transfer procedures and develop a core flow chart. All the transfer work was run according to the optimized process. We compared the effects before and after the optimized process was applied. Results: After the implementation of the optimized process management, the preparation time before transfer was reduced from (10.25 ± 2.45) min to (6.24 ± 2.56) min (P<0.001), the incidence rate of nursing defects decreased from 23.3% to 7.9% (P<0.001), and patients' relatives satisfaction was improved (P<0.001). Conclusion: The process management for the transfer of patients with severe brain diseases can enhance the high quality and efficient completion of transfer tasks, and promote the continuous improvement of transfer quality and improve patients' relatives satisfaction.