Abstract: Objective: To explore the effect of different absorb moisture materials on the wet surgical equipment package and to improve the sterility quality of surgical equipment package. Methods: Using random classification method, we observed 920 surgical instrument packages with different packaging materials, including single-layer cotton, double-layer cotton, special gauze absorbent pad and disposable medical absorbent paper. After the pressure steam sterilization process, we compared the incidence of wet packages. Results: The wet package rates of double-layer cotton in cotton or non-woven packaging were 10.4% and 20.0%, respectively, which was significantly different (P<0.05). The wet package rates of special gauze absorbent pad in cotton or non-woven packaging were 8.7% and 31.3%, respectively, which was significantly different (P<0.01). When using cotton as the outer package, the wet package rates of double-layer cotton and single-layer cotton were 10.4% and 24.3%, respectively, which was significantly different (P<0.05). When using cotton as the outer package, the wet package rates of special gauze absorbent pad and single-layer cotton had significantly different (P<0.05). Conclusion: When using the same absorbent material, the incidence of wet packages in cotton with double-layer cotton or special gauze absorbent pad were lower than that of non-woven packaging. When using different absorbent materials, single-layer cotton as the outer packaging and special gauze absorbent pad had the highest incidence of wet package in cotton and in non-woven packaging, respectively.