Abstract: Objective: To implement evidence for thirst management in ICU patients with orotracheal intubation into clinical practice and evaluate its effects, aiming to standardize nursing care. Methods: Guided by the framework of evidence-based continuous quality improvement, this study was conducted from April 2024 to June 2025. Based on the FAME (Feasibility, Appropriateness, Meaningfulness, Effectiveness) principle, 17 audit criteria were formulated. The process involved a baseline audit, evidence implementation, and outcome evaluation. We compared patients' thirst intensity, oral mucosa moisture, incidence of complications, nursing staff compliance, as well as nurses' knowledge level and evidence-based practice competence regarding thirst management in intubated patients before and after the evidence-based intervention. Results: Following the implementation, compliance with all 17 audit criteria significantly improved (P<0.05). Patient thirst scores decreased from 5.49±3.13 to 3.34±1.79, oral mucosa moisture improved from 2.31±0.92 to 3.02±0.82, and the incidence of complications (oral mucosa injury and tube biting) was reduced (P<0.05). Nurses demonstrated significant enhancements in their evidence-based knowledge and practical competence (P<0.05). Conclusion: Evidence-based practice founded on continuous quality improvement can effectively alleviate thirst, reduce complications, and enhance nurses' knowledge and practical skills in managing ICU patients with orotracheal intubation.

Key words: orotracheal intubation; thirst; evidence-based practice; evidence-based nursing