Abstract: Objective: To develop a Central Line-associated Bloodstream Infection (CLABSI) prevention and control platform for the Intensive Care Units (ICUs), and to explore its application effects, in order to provide references for the prevention and control of ICU CLABSI. Methods: Guided by user-centered design and human-computer interface theory, a systematic search was conducted for factors related to CLABSI and laboratory indicators in ICUs. The platform monitoring contents were incorporated to form the ICU CLABSI prevention and control platform. The platform was officially applied in 22 different level hospitals across the country in July 2023. A total of 101 ICU nurses from each hospital were conveniently recruited to evaluate the usability of the platform. The differences in indicators such as the incidence of CLABSI in patients, compliance rate of medical staff's operational behavior and nurses' satisfaction rate were compared before and after the application of the platform. Results: The usability evaluation scores of ICU nurses for the platform was 70.0±16.9, indicating good usability of the platform. After the application of the platform, the number of patients with CLABSI decreased from 10 cases (1.5%) to 0, the quarterly percentage change in the number of patients with CLABSI was -44.3%, with statistically significant differences (both P<0.05). Both the compliance rate of medical and nursing operations and nurses' satisfaction rate increased with statistically significant differences (both P<0.05). Conclusion: The CLABSI prevention and control platform for the ICU can reduce the occurrence of CLABSI, standardize medical and nursing operations, and improve the satisfaction of nursing staff. The platform is worth of promotion in the clinical practice.

Key words: ICU; Central Line-associated Bloodstream Infection; prevention and control platform