Abstract: Objective: To study the level of physical activity and its influencing factors in Hematopoietic Stem Cell Transplantation (HSCT) patients, and to provide references for further intervention to improve the physical activity in HSCT patients. Methods: A total of 217 patients with HSCT from 9 tertiary Grade-A hospitals in Beijing were included by convenient sampling method. The International Physical Activity Questionnaire, Hospital Anxiety and Depression Scale, Revised Piper Fatigue Scale, the Exercise Self-Efficacy Scale, and Social Support Scale were used to collect data. Results: In this study, 161 (74.19%) patients had insufficient physical activity, 44 (20.28%) patients had moderate physical activity, and only 12 (5.53%) patients had active physical activity. Ordinal Logistic regression analysis showed that age, depression, fatigue, social support level and whether with complications were the influencing factors of physical activity in HSCT patients (P<0.05). Conclusion: The physical activity in HSCT patients is insufficient. It is recommended to implement targeted measures to provide the patients with more activity guidance, so as to help them to know the disease accurately, and to improve their physical activity level.

Key words: Hematopoietic Stem Cell Transplantation; physical activity; anxiety and depression; fatigue; exercise self-efficacy; social support