Abstract: Objective: To explore the influencing factors of Intra-Abdominal Pressure in the process of enteral nutritional support among patients with severe stroke, and to provide references for monitoring Intra-Abdominal Pressure among patients with severe stroke. Methods: Totally 80 patients with severe stoke who received enteral nutrition were recruited and measured Intra-Abdominal Pressure by bladder pressure method within 1 week after admission. The influencing factors of Intra-Abdominal Pressure were investigated by self-designed questionnaire. Results: The 80 patients measured 1680 times of Intra-Abdominal Pressure and 22 patients have high Intra-Abdominal Pressure (297 times). Having abdominal distention was related to the high Intra-Abdominal Pressure (P<0.001). GCS 8 and mechanical ventilation were the influencing factors of Intra-Abdominal Pressure(P<0.05). Conclusion: If patients with severe stroke have low GCS score (GCS 8), with mechanical ventilation or having abdominal distention in the process of enteral nutrition, Intra-Abdominal Pressure measurement would be helpful. The results could guide safe nutrition support and provide references for adding nursing monitoring indicators.