Abstract: Objective: To investigate the effects of comprehensive cardiac rehabilitation on cardiopulmonary function and quality of life in patients with Heart Failure with preserved Ejection Fraction (HFpEF). Methods: A total of 142 patients with HFpEF admitted to the Department of Cardiology of a tertiary hospital in Jilin province were conveniently selected from October 2023 to October 2024. The participants were randomly divided into a comprehensive rehabilitation group of 68 cases and a control group of 74 cases. Those in the control group received only the conventional cardiac rehabilitation program, while those in the intervention group received a gradual and progressive cardiac rehabilitation program based on inspiratory muscle training, with both groups undergoing a 12-week intervention. Changes in inspiratory muscle strength, cardiopulmonary function were compared between the two groups before and after the intervention. Results: Sixty-five patients in each group completed the study. After the intervention, the maximum inspiratory pressure and peak inspiratory flow of the intervention group were (57.11±3.31) cmH2O and (3.87±1.14) L/s, respectively, which were significantly higher than those of the control group [(55.08±2.88) cmH2O and (2.91±1.27) L/s, P<0.05]. Additionally, the intervention group exhibited higher peak oxygen consumption and maximum ventilatory volume, as well as a lower Borg score, compared with the control group, with all differences being statistically significant (P<0.05). However, there was no statistically significant difference in the 6-minute walking distance between the two groups after the intervention (P>0.05). Conclusion: The integrated cardiac rehabilitation strategy based on inspiratory muscle training has significantly improved inspiratory muscle strength and endurance of patients with HFpEF, promoting the improvement of cardiopulmonary function and quality of life.

Key words: inspiratory muscle training; heart failure; maximum inspiratory pressure; cardiopulmonary function; quality of life