Abstract: Objective: To explore the application effect of closed-loop safety management of molecular targeted drug trastuzumab (herceptin). Methods: Using closed-loop concept and intelligent information management system, several steps were improved, including setting herceptin orders sheet, automatic calculation of dosage, a single-dose billing, medication donation standardization, centralized configuration, standardizing drug use check, and infusion process safety management. Results: The time of prescriptions and the time on the drug check increased (P<0.001). The times of first drug delivery and drug allocation were shortened (P<0.001). There was no significant difference in infusion time between the two groups (P>0.05). Adverse events of herceptin decreased significantly (P<0.001). Conclusion: The closed-loop safety management process of herceptin was a kind of the patient centered service, which could obviously improve the drug use safety, reduce the process errors and improve the efficiency of medical care.

Key words: trastuzumab; drug safety; the closed-loop management; medication