Abstract: Objective: To analysis the research hot of cardiovascular nursing research in core journals of the Web of Science database, provide the reference for the cardiovascular nursing research. Methods:Using the CiteSpace information visualization software, analyze about 3556 papers relate to cardiovascular diseases in nursing within 2006-2015 year in core journals of the Web of Science database, and draw knowledge graph about research hotspots and research frontier.Results:The number of published papers in cardiovascular nursing research show the tendency to increase within nearly one decade; research hot focus mainly on the keywords such as heart failure, coronary heart disease, high blood pressure,self-management, mortality and risk factors; research frontier focus on the disease which have high incidence in the elderly,such as heart failure and Alzheimer; research hot between China and the United States in the same time zone is not the same, Chinese research hot is five years later than the United States. Conclusion: Research hot spread out as the center of the heart failure, coronary heart disease and high blood pressure; Chinese published number of papers in SCI have a tendency to increase, but as a big country of cardiovascular disease, the number is too little compared to the United States and other developed countries, China should increase investment in cardiovascular nursing research.