Abstract: Objective: To explore the mediating effect of resilience on the relationship between rumination and Posttraumatic Growth in hemodialysis patients. Methods: Totally 218 patients with hemodialysis from the affiliated hospital of Qingdao University were assessed with the general information questionnaire, Posttraumatic Growth Inventory (PTGI),Connor-Davidson Resilience Scale (CD-RISC) and the Event Related Rumination Inventory (ERRI). Regression analysis and Bootstrap were used to test the mediating effect of resilience on the relationship between rumination and Posttraumatic Growth. Results: Posttraumatic Growth was positively correlated with resilience anddeliberate rumination (r=0.76 and r=0.55, P<0.01), and was negatively correlated with intrusive rumination (r=-0.14, P<0.05). Deliberate rumination was positively associated with Posttraumatic Growth (β=0.169, P<0.01). In addition, resilience mediated the relationship between rumination and Posttraumatic Growth, and the value of mediating effect was 6.1%. Conclusion: Resilience may play a partial mediating role between rumination and Posttraumatic Growth in hemodialysis patients.