Abstract: Objective: To explore the mode of hospital and college joint orientation training of ICU nurses. Methods: A total of 280 college students in Department of Nursing in Henan Medical College for Staff and Workers from March 2011 to June 2013 were trained according to Hospital and College Joint Orientation Training Program for ICU Nurses. Results: By the hospital and college joint orientation training of ICU nurses, the mean scores of theory, clinical practice, and the patients' satisfaction was 95.74, 97.89, and 99.38 respectively. The incidence of nursing adverse events was 1.78%. Conclusion: Hospital and college joint orientation training of ICU nurses, which emphasizes early intervention, joint collaboration and practicing, achieves a significant effect and is feasible.