Abstract: Objective: To investigate the current status of disability acceptance and alexithymia among patients with permanent colostomy, and to explore the effect of alexithymia on disability acceptance. Methods: Totally 222 patients with permanent colostomy were recruited and investigated by the Acceptance of Disability Scale and the Toronto alexithymia Scale. Results: The mean scores of disability acceptance and alexithymia were (180.45±33.25) and (2.99±0.79), respectively.The affective disorder of recognition, affective disorder of description, extroverted thinking and the total score of alexithymia were significantly negatively correlated with the each dimension and total score of disability acceptance (P<0.05). Hierarchical regression analysis showed that the affective disorder of recognition, affective disorder of description and extroverted thinking were the influencing factors of the disability acceptance among patients with permanent colostomy (P<0.05). Conclusions: The level of disability acceptance was in the medium level among permanent colostomy patients and alexithymia was its influencing factor. The nursing staff could take effective measures to intervene exithymia and to improve the level of disability acceptance among permanent colostomy patients.