Abstract: Objective: To establish a clinical process flow and management mode of potential critical diseases in pediatric emergency department, in order to recognize and treat patients early to reduce mortality and avoid medical conflicts. Method:The recognition process of pediatric emergency triage was established; clinical scheme for early screening of potential critical disease in pediatric emergency department was enacted. Result: From 2010 to 2013, after application of clinical recognition process and management mode, 10 cases of fulminant myocarditis, 9 cases of EV71-associated severe infection; 8 cases of pyemia and 2 cases of epidemic cerebrospinal meningitis were early recognized, which helped avoid 10 cases of medical conflicts. There were totally 7 cases of medical conflicts only, which were 8 cases less compared to the cases reported between 2006 and 2009.The death toll decreased to 118 from 163 before the intervention. Conclusion: The establishment of standard clinical process flow and management mode can increase the early recognition ability of medical staff in emergency department, which can obviously decrease mortality and medical conflicts.