Abstract: Objective: To analyze the application effect of the Early Goal-Directed Mobilization protocol in mechanically ventilated patients and provide a theoretical basis for promoting early activity in the ICU. Methods: A convenience sample of 60 mechanically ventilated patients admitted to the respiratory ICU of a tertiary grade A hospital in Ningxia from January to May 2024 was selected for this study. Patients admitted from January 1 to March 15 were assigned to the observation group (n=30), and those admitted from March 16 to May 29 were assigned to the intervention group (n=30). The observation group received routine nursing care, while the intervention group received the Early Goal-Directed Mobilization protocol. Various outcomes were compared between the two groups, including mechanical ventilation time, rate of out-of-bed activities, time to initiate early out-of-bed activities, ICU length of stay, ICU costs, and incidence of adverse events. Results: The intervention group had significantly shorter mechanical ventilation time, (10.89±2.16) days vs (13.13±2.70) days, higher rate of out-of-bed activities (80.0% vs 46.7%), earlier time to initiate out-of-bed activities, (3.10±0.91) days vs (6.87±1.84) days, shorter ICU length of stay, (8.39±1.60) days vs (14.59±3.37) days, lower ICU costs, (39104.86±4277.54) yuan vs (52492.48±7876.25) yuan, and lower incidence of pulmonary infection (3.3% vs 26.7%) and pressure injury (3.3% vs 30.0%) compared to the observation group, with statistical significance (P<0.05). Conclusion: The Early Goal-Directed Mobilization protocol can effectively promote the recovery of mechanically ventilated patients, reduce mechanical ventilation time and ICU length of stay, decrease the incidence of pulmonary infection and pressure injury, significantly reduce ICU costs, and notably increase the time to initiate early out-of-bed activities and the rate of out-of-bed activities. It is worthy of clinical application and promotion.

Key words: mechanical ventilation; Early Goal-Directed Mobilization; Multidisciplinary Team; critical care