Abstract: Objective: To investigate the status and influencing factors of frailty among inpatients with Chronic Kidney Disease (CKD) without renal replacement therapy, so as to provide evidence for early identification of high-risk groups and management of frailty. Methods: Using convenient sampling method, totally 311 inpatients with CKD without renal replacement therapy in a tertiary grade A hospital in Beijing were selected for a cross-sectional survey. The investigation tools include general information questionnaire, Tilburg Frailty Indicator (TFI), age-adjusted Chalson Comorbidity Index (aCCI), Global Leadership Initiative on Malnutrition (GLIM), Self-rating Depression Scale (SDS) and Perceived Social Support Scale (PSSS). Results: Totally 183 people (58.8%) evaluated by the Chinese version of TFI were frail among 311 respondents. The results of multivariate Logistic regression showed that malnutrition, severe co-morbidity and depression were risk factors of frailty among inpatients with CKD without renal replacement therapy (P<0.05), while high level of social support was its protective factor (P<0.05). Conclusion: The prevalence of frailty among inpatients with CKD without renal replacement therapy is high, attention should be paid to those people in their health management. Medical workers should take nutrition intervention, co-morbidity management, psychological intervention and social support system construction as important contents of frailty prevention and chronic disease management into consideration in clinical practice.

Key words: Chronic Kidney Disease; frailty; without renal replacement therapy; Chinese version of Tilburg Frailty Indicator