Abstract: It is crucial to prevent the occupational exposure of AIDS in the high risk working area. Unfortunately occupational exposure to AIDS occurs sometimes. Frontline medical staffs are under great pressure. In order to reduce the occurrence of AIDS occupational exposure, the following information are discussed: construction of occupational safety organization, development of precaution mechanism and preventive methods, enhancement of psychological counseling service, and improvement of humanistic care. It is expected to reduce the incidence of AIDS occupational exposure through the health intervention system.