Abstract: Objective: To investigate the relationship between resilience and family hardiness of patients with Inflammatory Bowel Disease (IBD). Methods: The self-designed general information questionnaire, the Chinese version of Connor-Davidson mental resilience scale (CD-RISC) and the Chinese version of Family Hardiness Index (FHI) were used to investigate 104 patients with IBD. Results: The total scores of CD-RISC and FHI of IBD patients were (62.53±14.97) and (58.61±5.95) respectively. In terms of dimensions, the scores of tenacity, strength and optimistic were (30.64±8.61), (22.34±4.96) and (9.55±2.82) respectively, and the scores of commitment, control and challenge were (27.38±3.05), (17.08±2.29) and (14.15±1.98) respectively. The Pearson analysis demonstrated that the total score and score of each dimension of CD-RISC were related with the scores of FHI (P<0.05). Multi-factor analysis showed that commitment, challenge and age could significantly predict the level of resilience (P<0.05). Conclusion: The family hardiness may be one of the influencing factors of resilience of IBD patients, and health care workers could improve family hardiness, and foster the family support to strengthen resilience of the patients with IBD, thus help the patients manage the psychological state and symptoms.