Abstract: Objective: To explore the current status and influencing factors of self-perceived burden among postoperative stoma patients. Methods: Totally 151 postoperative stoma patients were recruited to complete demographic questionnaire, Self-Perceived Burden Scale, Medical Coping Modes Questionnaire and Stoma-QOL scale. Results: The mean score of Self-Perceived Burden Scale was 39.62±8.81, which was in moderate level, with 50.3% patients in high level. The influencing factors of self-perceived burden of postoperative stoma patients include avoidance, educational level, stool leakage and stink rate and confrontation. Conclusion: Stoma patients has serious level of self-perceived burden. Nurses should encourage patients to face difficulties and challenges, learn stoma care skills, and communicate with others actively. Besides, stoma patients who has lower educational level should be paid more attention.