Abstract: Objective: To evaluate the effect of Music Therapy for premature infants through Meta-analysis. Methods:Relevant Randomized Controlled Trials (RCT) on music therapy for prematurity were retrieved from CENTRAL,EMBASE, PubMed, Web of Science, CNKI, CBM and Wanfang databases. The methodological quality of the eligible studies was assessed by two investigators independently. And Meta-analysis was conducted by RevMan 5.3. Results:Totally 11 eligible RCTs including 1182 premature infants were analyzed. The Meta-analysis revealed that average daily weight gain, weight in the 2nd week, intake of milk in the 5th day, intake of milk in the 10th of premature infants in music therapy group were higher than those in the control group (P<0.05). Length of hospital stays and heart rate in Music Therapy group were shorter or lower than those in the control group (P<0.05). No significant difference was identified in terms of oxygen saturation between the two groups (P>0.05). Conclusions: Music Therapy could help to increase intake of milk and weight in the 2nd week, shorten length of hospital stays, and reduce heart rate, but have no obvious effect on oxygen saturation.