Abstract: Objective: To evaluate the effects of cluster nursing on acute pressure ulcers prevention among cardiac surgery patients with extracorporeal circulation. Methods: High pressure ulcer risk patients with Braden score 12 within 24h in ICU from Feb. to Aug. 2014 were recruited and reviewed as control group(62 cases), while the similar patients in ICU from Dec. 2014 to June 2015 were recruited as observation group (111 cases). The observation group received cluster nursing intervention. Results: In the control group, 15 patients, 2 patients and 1 patient developed level I , level II level III pressure ulcers , respectively, The pressure ulcer rate in the control group was 29.03%. In the observation group, only 6 patients developed level I pressure ulcers. The pressure ulcer rate in observation group was 5.41%. The differences of pressure ulcer rate between the two groups was statistically significant (P<0.01). Conclusion: Cluster nursing could decrease the incidence of pressure ulcers among high risk cardiac surgery patients with cardiopulmonary bypass.