Abstract: Objective: To explore the effect of wechat public platform on continuing care for those as dominant caregivers of preschool children with epilepsy after discharge. Methods: We evenly distributed a total of 110 dominant caregivers of the epileptic children into the experimental group and the control group based on the sequence of their diagnosis record. The experimental group was treated with the individual care and the group management for three months after discharge via the wechat public platform. The treatment included individual follow-up interviews, disease knowledge delivery as well as group discussion. The follow-up interview consisted of care knowledge, medicine management and psychological intervention. The control group was given regular nursing guidance. Results: The level of disease knowledge in the experimental group was higher than that in the control group at one month and three months after discharge (P<0.05).The children's medication compliance in the experimental group was higher than it in the control group at three months after discharge (P<0.05). Conclusion: wechat public platform for continuing care service could improve dominant caregivers' knowledge of disease and children's medication compliance to ensure medical care results.