Abstract: Objective: To discuss the effect of flow-up management based on Structural Family Therapy for Cancer-Related Fatigue for patients with breast cancer during postoperative chemotherapy period. Methods: Patients with breast cancer during postoperative chemotherapy period were randomly assigned into control group (n=75) and intervention group (n=79). The control group received routine follow-up during chemotherapy period and the intervention group received follow-up based on Structural Family Therapy. Patients' levels of Cancer-Related Fatigue were compared at the end of the study.Results: After intervention, the score of physical fatigue (13.29±4.84), emotional fatigue (8.65±3.01), cognitive fatigue (9.06±3.12) and the total score of Cancer Fatigue Scale (31.20±11.02) were all lower than those of the control group(15.00±4.25, 10.04±3.24, 10.26±3.08, and 35.30±10.26) with statistically significant differences (P<0.05). Conclusion: The flow-up management based on Structural Family Therapy can effectively decrease the level of Cancer-Related Fatigue for patients with breast cancer during postoperative chemotherapy period.