Abstract: The clinical decision support is the advanced stage of informatization development. It is also the result of the integration of information system and decision support technology. The research on and the development of clinical decision supporting information system is of great significance to ensure the safety of critically ill patients. This article has mainly summarized the system's development team and running platform, the only source of basic information among patients, automatic extraction, the intelligent error correction of bedside monitoring information, tendency analysis, the closed-loop control, early warning prompt of clinical process information and related nursing observation record, smart reminder, sharing medical resource, information consistency, comprehensive and intensive research and development of information system were introduced as the key technical points. For the hope of our efforts would offer help in informationized construction.