Abstract: Objective: To investigate the current status of caregiver reaction and resilience among cervical spinal cord injury patients with paraplegia, and to explore the influencing factors of caregiver reaction on resilience. Methods: Totally 203 cervical spinal cord injury patients with paraplegia and their caregivers were recruited and investigated by the Connor-Davidsen Resilience Scale and the Caregiver Reaction Assessment Scale. Results: The scores of health problems, disturbed time arrangements, economic problems, lack of family support, and self-esteem were 10.96±2.39, 16.34±3.60, 7.74±1.30,17.91±4.22 and 26.76±6.42, respectively. The total score of resilience was 62.80±17.65. The scores of health problems,disturbed time arrangements, economic problems, lack of family support were negatively correlated with the scores of tenacity, strength, optimism and total score of resilience (P<0.05), while the score of self-esteem were positively correlated with the scores of tenacity, strength, optimism and total score of resilience (P<0.05). Hierarchical regression analysis showed that all the dimensions of caregiver reaction could explained 24.4% of the total variance of the resilience among cervical spinal cord injury patients with paraplegia (P<0.05). Conclusions: The resilience among cervical spinal cord injury patients with paraplegia was in the middle level, and the caregiver reaction is an important influencing factor of resilience.The nursing staff could improve the level of patients' resilience by handling with their caregiver reaction.