Abstract: Objective: To investigate the knowledge and attitude to palliative and terminal care in medical college students and to explore the coping strategies. Methods: This cross-sectional study was carried out in 3 medical universities in Liaoning province. The influencing factors were analyzed by ANOVA and multiple regression analysis. Results: No significant difference was found among students with different medical specialties in the total scores of palliative care attitude (P>0.05). However, students majoring in nursing had statistically higher scores in the dimensions of the attitude on carrying out palliative care, self-assessment of palliative care knowledge, and the attitude on death education (P<0.05).Whether family members or themselves having experiences of suffering from serious disease entered the regression equation for general score of palliative care knowledge, explained 55.9% of variation. While genders and palliative care knowledge level were influencing factors of palliative care attitude by regression analysis, explained 4.8% of variation.Conclusion: There were statistically significant differences among students with different medical specialties in some dimensions of palliative care attitude. More attention should be paid on life education for students majoring in medical Imaging, anesthesiology and dentistry, and enlarge the influence of internet and other paths for medical students education.