Abstract: As an era of genome/genomics and utilization of the big data is emerging to health practice, precision medicine will become the inevitable trend in the medical and nursing science development. Under this rapid genomic advancement, the practice concept, health service content, and health related consultation of health care professionals will be profoundly changed. Integrating genomic science in practice, pediatric care that focus on individual characteristics will be achieved practically. As an important service provider, nurses must advance professional career by knowing impacts of genomics advances to their patients and family. Nurses, in fact, will become the core members of integrating practice from multidiscipline to provide a comprehensive care for patients. Nursing specialists from UCL gene therapy center have demonstrated this important role. However, current existing gap in genomic nursing is that clinical nurses do not demonstrate adequate skill to utilize genomics technology to observe and evaluate the risk of genomic related diseases, to provide relevant genomic therapy information for patients and their families, and to educate patients for diseases self-care. In the future,the genome/genomics knowledge should be included in the undergraduate nursing curriculum, and must provide updated information in genome/genomics clinical usage for clinical nurses, who then could possess academic and innovative thinking to carry out genome/genomics nursing practice to better serve patients and family in the near future.