Abstract: Objective: To investigate the current status and influencing factors of parenting stress among parents of asthma children. Methods: A total of 274 asthma children and their parents were recruited from three teriary hospitals in Wenzhou by convenience sampling method. They were investigated with a self-designed demographic questionnaire, Parenting Stress Index-Short Form, and Childhood Asthma Control Questionnaire. The influencing factors of parenting stress were analyzed by using multiple stepwise regression analysis. Results: The main score of parenting stress among parents of asthma children was 143.39±19.48. Multiple linear regression analysis showed that the age of children, education level of parents, and childhood asthma control degree were influencing factors of parenting stress among parents of asthma children. Conclusion: Clinical nurses should pay more attention to the parenting stress among parents of asthma children,and promote the childhood asthma control degree to decrease the parenting stress among parents of asthma children.