Abstract: Objective: To investigate the level of symptom burden among Maintenance Hemodialysis patients and explore the correlation between symptom burden and sleep quality, quality of life. Methods: Totally 143 maintenance hemodialysis patients from Xiangya Hospital and the Third Xiangya Hospital of Central South University from May, 2013 to May, 2014 were recruited, general demographic data questionnaire, Dialysis Symptom Index (DSI), Pittsburgh sleep Quality Index (PSQI), and SF-36 were used to assess symptom burden, sleep quality and quality of life in maintenance hemodialysis patients. Results: The mean score of symptom burden was (76.69±37.95), the average symptom number was(13.12±5.27). The PSQI showed that 116 cases (81.11%)suffered sleep disorder, the mean score of PSQI was (10.96±4.46). Spearman correlation test showed the symptom burden was correlated positively with the sleep quality (r=0.527), and negatively with quality of life (r=-0.599~-0.200). Conclusion: Most maintenance hemodialysis patients suffered severe and many symptoms at the same time. Sleep quality and the quality of life were generally low, and symptom burden were correlated with the sleep quality and quality of life. Nurses should instruct patients to improve sleep quality and manage symptoms in order to reduce symptom burden and improve patients' quality of life.