Abstract: Objective: To explore the standard module construction and the effect evaluation of nursing comprehensive practice project based on the high simulation human. Methods: Using heart failure case as example, the standard module oriented with professional ability training was built. Then 48 students got trained with this module and the teaching effects were evaluated.Results: The scores of three dimensions named clinical decision, professional knowledge & skills and communication were the lowest according to students' self report. The teachers' records showed that the expected nursing measures were not implemented timely and correctly. Conclusion: Comprehensive training project is a good platform for occupational ability training of nursing students. Teachers should help students transform their knowledge and skills to the clinical execution, and strengthen students' communication ability training in the teaching process. The appropriate evaluation system for the project also needs to be set up.