Abstract: Objective: To develop a specific Stroke Premonitory Symptoms Alert Questionnaire (SPSAQ) , and to test the validity and reliability of the scale. Methods: Totally 290 cases with stroke risk and their families were recruited using the convenience sampling method to test the internal consistency, face validity, content validity and discriminant validity of the questionnaire. We tested test-retest reliability of the questionnaire using a convenient sample of 96 cases with stroke risk and their families. Results: We finally got a 9 items of SPSAQ. The CVI, KR-20, and test-retest reliability of the SPSAQ was 0.84, 0.798 and 0.729, respectively. Items difficulty (P) and degree of differentiation (D) ranged from 0.63 to 0.86 and 0.24 to 0.75, respectively.Conclusions: SPSAQ has good reliability and validity which indicate the initial objective of the scale development.