Abstract: Objective: To explore the effect of applying Quality Control Circle (QCC) to improve instrumental cleaning quality. Methods: We carried out QCC activities, grasped the current situation, analyzed the cause of incomplete instrumental cleaning, developed and implemented the strategies, and attained the continuous quality improvement. Results: The unqualified instrumental cleaning rate decreased from 2.30% to 0.58% by visual inspection before and after the implementation, and the difference was statistically significant (P<0.01). Conclusion: The QCC can effectively improve the quality of medical instruments cleaning quality.