Abstract: Objective: To apply the best evidence of prevention and management of perioperative Venous Thromboembolism to clinical practice and to evaluate its effect. Methods: According to the evidence-based clinical transformation model of Fudan University Evidence-based Nursing Center, and to formulate strategies based on the current clinical situation. From August 2021 to May 2022, 215 patients and 323 nurses working in 13 surgical wards of a tertiary grade A hospital in Beijing were selected as subjects using convenience sampling method. The cognitive level of knowledge about Venous Thromboembolism and the implementation rate of review criteria were compared between nurses and patients before and after intervention. Results: The scores of nurses' knowledge about Venous Thromboembolism before and after intervention were 79.13±13.97 and 87.37±12.91, and the difference was statistically significant (t=7.571, P<0.05). Before and after intervention, the scores of patients' knowledge related to Venous Thromboembolism were 4.55±2.11 and 6.52±1.75, and the difference was statistically significant (t=-7.456, P<0.05). The implementation rate of all the indicators after intervention was higher than that before intervention, and the difference was statistically significant (P<0.05). Conclusion: The formulation and application of best practices can improve patients' awareness and self-management to prevent perioperative Venous Thromboembolism, enhance nurses' compliance with the implementation of the best evidences, and promote the continuous improvement of nursing quality.

Key words: perioperative period; Venous Thromboembolism; best evidence; evidence-based practice