Abstract: Objective: To develop an evidence-based Clinical Decision Support protocol about pediatric Parenteral Nutrition administration. Methods: Based on GRADE Evidence to Decision Framework, we sorted out the key issues through on-site observation, including intravenous catheter selection, medication administration assessment, searched the evidence, proposed the primary protocol, and finally made the final clinical decision and the proper pathway of each piece of included evidence, through multi-disciplinary expert discussion. Results: A knowledge base that contained 25 pieces of evidence was developed, and a 5-functional Clinical Decision Support protocol, which included automatic association, intelligent trigger, information push, template generation, reminder/warning. Conclusion: Based on GRADE Evidence to Decision Framework, the Clinical Decision Support protocol developed in this study is scientific, feasible and with practical guiding significance.

Key words: GRADE Evidence to Decision Framework; Clinical Decision Support system; Parenteral Nutrition; pediatrics