Abstract: Objective: To systematically evaluate the experience of reproductive decision-making in women of childbearing age with breast cancer, and provide references for the management of reproductive decision-making in this population. Methods: The databases in Chinese and English were systematically searched from the inception to June 2022 to collect the qualitative research about reproductive decision-making in women of childbearing age with breast cancer. The literature quality was evaluated by the JBI appraisal standards for qualitative research. Findings of included research were synthesized using the pooled integration approach. Results: A total of 11 studies were included and 36 findings were extracted, which were summarized into 9 categories and integrated into 4 results, including the need for fertility in women of childbearing age with breast cancer patients; fertility anxiety related with health uncertainty; multiple dilemmas in reproductive decision-making; auxiliary supports for fertility decision-making. Conclusion: Medical staff should pay attention to the decision-making experience in women of childbearing age with breast cancer in the process of diagnosis and treatment, provide supports to get rid of decision-making difficulties and worries, provide adequate information support, and encourage them to make personalized reproductive decisions.

Key words: childbearing age; breast cancer; fertility decision-making; real experience; qualitative research; Meta-synthesis