Abstract: Objective: To evaluate and analyze guidelines, expert consensus and systematic reviews of early eye care in newborns after delivery, so as to provide guidance for medical and nursing staff to make better decisions on newborn outcomes. Methods: We searched literature systematically from guideline development websites, newborns and delivery related professional societies and databases. The AGREE II, JBI quality assessment tool and AMSTAR 2 Tool were used for quality evaluation for guidelines, expert consensus and systematic reviews, respectively. We then evaluated the levels of evidence and strengths of recommendations for the evidence summary. Results: A total of 9 neonatal eye care related guidelines, 1 expert consensus and 1 systematic review were included. We synthesized the findings from four dimensions, including eye drying, eye care, eye examination, and screening of pregnant women and their partners for Sexually Transmitted Diseases (STD). Conclusion: It is recommended to dry the eyes immediately after delivery and do a follow-up eye examination for neonates. Erythromycin eye ointment should be applied to the eyes of newborns with potential exposure to STD to prevent the occurrence of ophthalmitis. Meanwhile, screening and treatment of STD among pregnant women and their partners should be strengthened in the future.

Key words: ophthalmia neonatorum; guideline; systematic review; evidence summary