Abstract: Objective: To investigate the incidence of Cancer-Induced Fatigue in lung cancer patients with chemotherapy at different stages of treatment, and to analyze the factors related to the occurrence of Cancer-Induced Fatigue. Methods: The general data questionnaire and the cancer fatigue scale were used to evaluate the cancer fatigue status of 249 patients in a hospital in Shanghai from December 2020 to December 2021 before the first chemotherapy and the first to six chemotherapy at seven-time points, and the influencing factors of cancer fatigue were analyzed by multivariate logistic regression. Results: The incidence of Cancer-Induced Fatigue in lung cancer patients undergoing chemotherapy was 44.9% to 50.4% for the first time. The degree of fatigue was mainly mild, and the degree of fatigue showed an upward trend with chemotherapy. The degree of fatigue was the most severe after the fourth chemotherapy. Occupation, mode of residence, household per capital monthly income, BMI index, chronic diseases (stroke, hypertension), cough, vomiting, and red blood cell count were factors influencing cancer fatigue in lung cancer patients at different stages of chemotherapy (P<0.05). Conclusion: The influencing factors of Cancer-Induced Fatigue in different treatment periods of lung cancer chemotherapy patients are different, and clinically patients should be given different attention and interventions from physiological, psychological and social dimensions at different treatment periods, and gradually promote patient recovery.

Key words: Cancer-Related Fatigue; influencing factors; lung cancer; chemotherapy