Abstract: Objective: To investigate the effects of intensive rehabilitation program on patients with traumatic brain injury (TBI). Methods: Fifty-three TBI patients from January to October in 2016 were included in control group. During the daytime, they received a comprehensive rehabilitation program, including physical therapy, occupational therapy, speech therapy and psychotherapy; in the night, they received usual rehabilitation nursing, supervised and assisted by families or caregivers for self-exercise. Meanwhile, 51 TBI patients were included in the intervention group, and they received intensive rehabilitation program in combination with the programs received in control group. After the interventions, standard assessments on cognition, motor function and activity of daily living were conducted for all patients using Mini-Mental State Examination (MMSE), Fugl-Meyer Assessment Scale and Barthel Index scale, respectively. Results: After the interventions, the scores of MMSE, Fugl-Meyer and Barthel Index were significantly improved (P<0.05) in both groups. Moreover, patients in the intervention group had higher scores based on the three assessments as compared with the control group (P<0.05). Conclusion: Intensive rehabilitation program could further improve the effectiveness of rehabilitation among TBI patients from the perspective of nursing. It could be considered as a new working model for nurses, and is worthy of being generalized for TBI's rehabilitation in major hospitals.