Abstract: Objective: To analyze effects of the Technology Acceptance Model in application of pressure injury management software. Methods: Based on the Technology Acceptance Model, a plan was developed to popularize the pressure injury management software, which includes: optimizing software performance, establishing standard operating procedures and popularizing softwares in different phases (trial phase, growing phase and consolidating phase), along with software training and support. From March 2016 to June 2017, this software was employed in 3 tertiary Grade A hospitals and 2 tertiary grade B hospitals with mature foundation of nursing information system in a certain province. Besides, "Quality Evaluation System of Pressure Injury Prevention in Hospitalized Patients" and "Satisfaction Evaluation System of Pressure Injury Management Softwares" were adopted respectively to evaluate the usefulness and ease of software application. Results: After implementation of the promotion program, the five hospitals acquired certain achievements in terms of increasing accuracy of pressure injury and risk degree assessment, higher accuracy of pressure injury prevention measures and the corresponding quality control measures (P<0.05). The incidence of pressure injury acquired in hospitals decreased from 2.25% to 0.65%. The average time consumed on risk assessment of pressure injury by different levels of nurses reduced from (3.43±2.69) min to (2.57±2.08) min. As to the ease of using the pressure injury management software, the overall satisfaction was 93.9%. Conclusion: The Technology Acceptance Model, which can help to improve the effectiveness of pressure injury management, enhance nurse satisfaction and get good promotion effects, is feasible and worthy of reference in popularization of pressure injury management softwares.