Abstract: Objective: To translate the Challenging Behavior Scale (CBS) into Chinese and evaluate its reliability and validity. Methods: The Chinese version of CBS (CCBS) was translated from the original English version, back-translated and adjusted for cultural adaptation. The reliability and validity were tested in 244 caregivers of patients with Alzheimer disease. Results: The scale-level content validity index (S-CVI) of the CCBS was 0.94, and the item-level content validity index (I-CVI) of the CCBS was 0.80~1.00, which indicated a desirable content validity. Factor analysis extracted 2 common factors, which explained 56.567% of variance of the total scale, and each item had high factor loading (>0.4). The Cronbach's α was 0.827, and test-retested reliability was 0.892. Conclusion: The Chinese version of CBS has been proved to be valid and reliable. It is a valuable tool for evaluating the Challenging Behavior among patients with Alzheimer disease.