Abstract: Objective: To implementing best evidence-informed practice of skin toxicity caused by EGFRIs, to improve the nurses' compliance of skin toxicity symptom management, to decrease the incidence and severity of patients' skin toxicity, and to improve the patients' quality of life. Methods: We adopted the standard procedure of Practical Application of Clinical Evidence System (PACES) of JBI evidence-based nursing center, and obtained the best related practice evidence in the Clinical Online Network of Evidence for Care and Therapeutics (COnNECT+) database of JBI, and formulated corresponding review criteria. The data were collected by field observation, interviews, and medical records. Results: About 5 criterion in the second audit achieved 100.00% compliance. The patients' score of Skindex-16 was reduced from 25.18±17.29 to 7.59±6.79 (P=0.001). Conclusion: Audit of current practice and the implementation of strategies to improve compliance with evidence-informed practice were effective and appeared to reduce the incidence and severity of common EGFRIs-induced skin toxicities.