Abstract: Objective: To investigate the effect of comprehensive and systematic interventions on depressive symptoms of caregivers of patients with Alzheimer's Disease. Methods: 80 caregivers of patients with Alzheimer's Disease from tertiary hospitals in Kunming were chosen and randomly divided into the control group (n=40) and the experimental group (n=40). Basic interventions, thematic interventions and short-term group CBT were provided for each patient in the experimental group, while no specific training was supplied to the control group. 2 months after the intervention, all subjects were evaluated through scales including SCL-90, SDS, LES and HADM. Results: After the intervention, scores of SCL-90, SDS, LES, and HADM of the two groups both decreased significantly (P<0.05). The scores of SCL-90, SDS, LES, and HADM of the experimental group were lower than those of the control group (P<0.05). Conclusion: The comprehensive and systematic intervention could effectively alleviate depressive symptoms of caregivers of patients with Alzheimer's Disease. We suggest the comprehensive intervention should be applied widely to the community.