Abstract: Objective: To analyze the role of programmed nursing intervention in improving the breastfeeding rate of premature and extremely low birth weight newborns. Methods: The programmed nursing intervention for prematurity and extremely low birth weight newborns was implemented in neonatal intensive care unit, including setting up the programmed intervention team, promoting early lactation intervention, using PDCA method to maintain lactation, encouraging early skin contact and oral intervention, and giving programmed nursing intervention after discharge, etc. Results: The breastfeeding rate and growth rate of preterm and low birth weight newborns of neonatal intensive care unit were significantly improved. Conclusion: The programmed nursing intervention model has positive effect on promoting breast feeding rate and growth rate of preterm birth and low birth weight newborns.