Abstract: Objective: To investigate the recognition and extent to clinical alarms fatigue among ICU nurses and to identify the barriers and current status of alarms management. Methods: Totally 622 nurses in a tertiary Grade A comprehensive hospital in Jilin province were recruited and investigated using questionnaires about cognitive status, fatigue extend, clinical alarm management obstacles and alarm management status and we analyzed the influencing factors. Results: The highest score of nurses' recognition of alarm fatigue was "staff sensitive to alarm, quick response". The average score of nurses' alarm fatigue was 19.50±6.40. Among them, anxiety and mental stress fatigue score were the highest. The difference of fatigue extend scores among nurses with different working years and professional titles was statistically significant (P<0.05). Nurses were facing difficulties in improving alarm status, the top three were "frequent false alarm reduces the attention and response to alarms", "difficulties to understand the alarm priorities", " difficulties to hear the alarm in time". Conclusion: The nurses’ attitude to alarm fatigue are positive. The psychological fatigue is more serious than physical fatigue. There are fatigue differences among nurses with different working years and professional titles. The false alarm is a major obstacle to the clinical response of nurses. The management response to alarms is insufficient. We need to take targeted intervention and management measures in future to effectively reduce the alarm harm and guarantee quality and safety of nursing care in ICU.