Abstract: Objective: To explore the effect of Six Sigma DMAIC process management in improving the quality of pediatric specialized nurse training. Methods: The Six Sigma DMAIC process management was introduced to the pediatric specialized nurse training, and the results of training were evaluated. Results: The systematic training model based on Six Sigma DMAIC process management was developed, and the students' knowledge and core competencies was significantly improved. Conclusion: The systematic training conforms to the development of pediatric specialized nursing, and can be generalized in the future.