Abstract: Objective: To evaluate the impact of Intermittent Subglottic Secretion Drainage (ISSD) on Ventilator-Associated Pneumonia (VAP) related to critical illness. Methods: Cochrane Library, Pubmed, Excerpta Medica Database, Web of Knowledge, CBMdisc, CNKI, and Wanfang Database were searched for the Randomized Control Trials (RCTs) on the ISSD effect on VAP prevention, while the reference lists of all included studies were also reviewed. Two authors independently screened all the literatures, extracted data and assessed the quality of included studies. All eligible analyses were performed using Review Manager, Version 5.3. Results: Nine eligible trials with total of 1 225 patients (including 2 Chinese and 6 English papers) were included in the analysis. ISSD could decrease the VAP incidence, including early-onset VAP and late-onset VAP. It also could shorten the ICU days, duration of mechanical ventilation duration and hospital days (P<0.05), but there was no significant difference in mortality (P>0.05). Conclusion: ISSD might be associated with lower VAP incidence, but it did not clearly decrease patients' mortality.