Abstract: Objective: To investigate the sense of career success and its influencing factors among nurses with master or higher degree. Methods: A total of 1 510 nurses with master or higher degree from tertiary hospitals in 22 provinces were investigated with the Career Success Scale (CSS). Results: The average score of CSS was 3.17±0.69. The scores of the three dimensions were career satisfaction (3.23±0.79), inside competitiveness (3.18±0.85), outside competitiveness (3.07±0.87) respectively. Multiple linear regression analysis showed that nurses satisfied with monthly income, meeting job wishes, having participated in academic conferences, not participating in theoretical teaching at nursing school, working at a clinical department, hosting the continuing education program, having published SCI papers, undertaking a teaching position, with learning experience abroad and doctor degree had higher CSS scores, these factors explained 26.6% of the total variance. Conclusion: The sense of career success in nurses with master degree or above was at a moderate level and was influenced by multiple factors. It is suggested that nursing managers should provide personalized positions and working contents in line with the nurses' job wishes and training objectives, which can improve nurses' sense of career success.