Abstract: Objective: To develop a quantitative evaluation tool for assessing safety of catheters in adults with indwelling PICC at home. Methods: Delphi expert consultation and face to face interviews with patients were used under the guidence of nursing practice standards of infusion treatment of Intravenous Nurses Society (INS) (2011th Edition), in order to develop and establish an assessment tool to record and assess patients' subjective perceptions about occurance of complications related to PICC at home. Results: Expert positive coefficient of three rounds of expert consultation was 88.9%, 100% and 94.4%, respectively. The expert authority coefficient was 0.89. The Cronbach alpha coefficient of Self Perception Scale of Adult Patients with PICC at Home was 0.83, including 9 first-level indicators, such as pain, skin ulceration, local bleeding, catheter displacement, arm swelling, limitation of activity, catheter damage, subjective symptoms and abnormal temperature, whose Cronbach alpha coefficient was all beyond 0.70. Kendall coordination coefficient (W) significant test was statistically significant (P<0.001). Conclusion: This study was reliable and accurate. The assessment tool established could be used for transitional observation of PICC catheters between home and hospital. It can be used as an assessment tool for PICC patients in the home.